Mary-Catherine Lader, President and COO of Uniswap Labs, has stepped down after four years leading the development company behind one of the most prominent decentralized exchanges (DEX).
A former BlackRock executive, Lader joined Uniswap in 2021 to help bridge traditional finance and decentralized protocols.
During her tenure, Uniswap Labs expanded the protocol’s reach across multiple blockchains, launched its own mobile wallet, and matured into an infrastructure provider relied on by institutions, developers, and retail users alike. A successor has not been named.
Her exit also comes at a time when Uniswap’s regulatory standing has stabilized after facing multiple challenges over the past year.
In April 2024, the company received a Wells notice from the U.S. Securities and Exchange Commission (SEC), signaling potential enforcement action over alleged unregistered broker and exchange activity.
Later, in September 2024, Uniswap Labs settled with the CFTC, agreeing to pay a $175,000 fine for illegally offering leveraged digital asset derivatives through its interface, specifically, tokenized products that the agency deemed margined commodity contracts.
Since then, the broader U.S. policy environment has shifted. Under President Donald Trump, the White House has thrown its support behind crypto via the GENIUS Act, a proposed national bitcoin reserve, and calls for “clear and simple” regulatory frameworks.
Trump has described himself as the “crypto president,” and Congressional momentum is building around market structure legislation. Lader departs with Uniswap standing strong, anchored by over $5.3 billion in total value locked, according to DeFi Llama.